HHMI, Janelia Farm Research Campus
& Cold Spring Harbor Laboratory
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HHMI, Janelia Farm Research Campus & Cold Spring Harbor Laboratory
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Check out our publications for any given year. Leave blank for all references. |
| 1. | Huber D, Petreanu L, Ghitani N, Ranade S, Hromádka T, Mainen Z, Svoboda K. (2007) Sparse optical microstimulation in barrel cortex drives learned behaviour in freely moving mice. Nature 451, 61 -64 . PDF |
| 2. | Harvey C, Svoboda K. (2007) Locally dynamic synaptic learning rules in pyramidal neuron dendrites . Nature 450, 1195 -1200 . PDF |
| 3. | Sobczyk A, Svoboda K. (2007) Activity-dependent plasticity of the NMDA-receptor fractional Ca2+ current. Neuron 53(1), 17 -24 . |
| 4. | Petreanu L, Huber D, Sobczyk A, Svoboda K. (2007) Channelrhodopsin-2-assisted circuit mapping of long-range callosal projections. Nat Neurosci 10(5), 663 -668 . PDF |
| 5. | Bureau I, von Saint Paul F, Svoboda K. (2006) Interdigitated Paralemniscal and Lemniscal Pathways in the Mouse Barrel Cortex. PLoS Biol 4, 2361 -2371 . PDF |
| 6. | Gray NW, Weimer RM, Bureau I, Svoboda K. (2006) Rapid Redistribution of Synaptic PSD-95 in the Neocortex In Vivo. PLoS Biol 4, 2065 -2075 . PDF |
| 7. | Knott GW, Holtmaat A, Wilbrecht L, Welker E, Svoboda K. (2006) Spine growth precedes synapse formation in the adult neocortex in vivo. Nat Neurosci 9, 1117 -1124 . PDF |
| 8. | Scheuss V, Yasuda R, Sobczyk A, Svoboda K. (2006) Nonlinear [Ca2+] Signaling in Dendrites and Spines Caused by Activity-Dependent Depression of Ca2+ Extrusion. JNeurosci 26, 8183 -8194 . PDF |
| 9. | Holtmaat A, Wilbrecht L, Knott GW, Welker E, Svoboda K. (2006) Experience-dependent and cell-type-specific spine growth in the neocortex. Nature 441, 979 -983 . PDF |
| 10. | Svoboda K & Yasuda R. (2006) Principles of Two-Photon Excitation Micrscopy and its Application to Neuroscience. Neuron 50, 823 -829 . PDF |
| 11. | Yasuda R, Harvey CD, Zhong H, Sobczyk A, van Aelst L, Svoboda K. (2006) Supersensitive Ras activation in dendrites and spines revealed by two-photon fluorescence lifetime imaging. Nat Neurosci 9, 283 -291 . PDF |
| 12. | De Paola V, Holtmaat A, Knott G, Song S, Wilbrecht L, Caroni P, Svoboda K. (2006) Cell type-specific structural plasticity of axonal branches and boutons in the adult neocortex. Neuron 49, 861 -875 . PDF |
| 13. | Karpova AY, Tervo DGR, Gray NW, Svoboda K. (2005) Rapid and Reversible Chemical Inactivation of Synaptic Transmission in Genetically Targeted Neurons. Neuron 48, 727 -737 . PDF |
| 14. | Shepherd GMG, Svoboda K. (2005) Laminar and columnar organization of ascending excitatory projections to layer 2/3 pyramidal neurons in rat barrel cortex. J. Neurosci 25, 5670 -5679 . PDF |
| 15. | Sobczyk A, Scheuss V, Svoboda K. (2005) NMDA receptor subunit-dependent [Ca2+] signaling in individual hippocampal dendritic spines. J. Neurosci 25, 6037 -6046 . PDF |
| 16. | Portera-Cailliau C, Weimer RM, Paola VD, Caroni P, Svoboda K. (2005) Diverse Modes of Axon Elaboration in the Developing Neocortex. PLoS Biol 3, e272 . PDF |
| 17. | Shepherd GMG, Stepanyants A, Bureau I, Chklovskii DB, Svoboda K. (2005) Geometric and functional organization of cortical circuits. Nat Neurosci 8, 782 -790 . PDF |
| 18. | Egger V, Svoboda K, Mainen ZF. (2005) Dendrodendritic synaptic signals in olfactory bulb granule cells: local spine boost and global low-threshold spike. J Neurosci 25, 3521 -3530 . PDF |
| 19. | Holtmaat AJ, Trachtenberg JT, Wilbrecht L, Shepherd GM, Zhang X, Knott GW, Svoboda K. (2005) Transient and persistent dendritic spines in the neocortex in vivo. Neuron 45, 279 -291 . PDF |
| 20. | Svoboda, K. (2004) Do Spines and Dendrites Distribute Dye Evenly?. Trends in Neurosci. 27, 445 -446 . PDF |
| 21. | Nimchinsky EA, Yasuda R, Oertner TG & Svoboda K. (2004) The Number of Glutamate Receptors Opened by Synaptic Stimulation in Single Hippocampal Spines . Journal of Neuroscience 24, 2054 -2064 . PDF |
| 22. | Wang Y, Guo H, Pologruto TA, Hannan F, Hakker I, Svoboda K & Zhong Y. (2004) Stereotyped Odor-evoked Activity in the Mushroom Body of Drosophila Revealed by GFP-Based Ca2+ Imaging. J. Neuroscience 24, 6507 -6514 . PDF |
| 23. | Brecht M, Fee MS, Garaschuk O, Helmchen F, Margrie TW, Svoboda K, Osten P. (2004) Novel approaches to monitor and manipulate single neurons in vivo. J Neurosci. 24, 9223 -9227 . PDF |
| 24. | Zito K, Knott G, Shepherd GM, Shenolikar S, & Svoboda K. (2004) Induction of spine growth and synapse formation by regulation of the spine actin cytoskeleton. Neuron 44, 321 -334 . PDF |
| 25. | Chklovskii, D. B., Mel, B. W., & Svoboda, K . (2004) Cortical rewiring and information storage . Nature 431, 782 -788 . PDF |
| 26. | Pologruto, T.A., Yasuda, R., & Svoboda, K. (2004) Monitoring Neural Activity and [Ca2+] with Genetically Encoded Calcium Indicators. J. Neuroscience 24, 9572 -9579 . PDF |
| 27. | Chen B, Trachtenberg JT, Holtmaat AJ, Svoboda K. (2004) Long-term, high-resolution imaging in the neocortex in vivo. In: Spector D, editor. Live Cell Imaging. Cold Spring Harbor: Cold Spring Harbor Press -, . |
| 28. | Yasuda R, Nimchinsky EA, Scheuss V, Pologruto TA, Oertner TG, Sabatini BL, Svoboda K. (2004) Imaging calcium concentration dynamics in small neuronal compartments. Science STKE 219, P5 . PDF |
| 29. | Maravall, M., Koh, I.Y.Y., Lindquist, W.B., Svoboda, K. (2004) Experience-dependent changes in basal dendritic branching of layer 2/3 pyramidal neurons during a critical period for developmental plasticity in rat barrel cortex. Cerebral Cortex 14, 655 -664 . PDF |
| 30. | Bureau I, Shepherd GMG, Svoboda K. (2004) Precise development of functional and anatomical columns in the neocortex. Neuron 42, 789 -801 . PDF |
| 31. | Maravall M, Stern EA, Svoboda K. (2004) Development of intrinsic properties and excitability of layer 2/3 pyramidal neurons during a critical period for sensory maps in rat barrel cortex. J Neurophysiol. 92, 144 -156 . PDF |
| 32. | Holtmaat AJ, Wilbrecht L, Karpova A, Portera-Cailliau C, Burbach B, Trachtenberg JT, Svoboda K. (2004) Long-term, high-resolution imaging of neurons in the neocortex in vivo. In: Yuste R, Konnerth A, editors. Imaging Neurons. Cold Spring Harbor: Cold Spring Harbor Laboratory -, . |
| 33. | Egger V, Svoboda K & Mainen ZF. (2003) Mechanisms of lateral inhibition in the olfactory bulb: efficiency and modulation of spike-evoked calcium influx into granule cells. J Neurosci 23, 7551 -7558 . PDF |
| 34. | Pologruto, T.A., Sabatini, B.L., & Svoboda, K. (2003) ScanImage: Flexible software for operating laser scanning microscopes. Biomedical Engineering Online 2:, 13 . PDF |
| 35. | Yasuda, R., Sabatini, B.L., and Svoboda, K. (2003) Plasticity of calcium channels in dendritic spines. Nature Neuroscience 6, 948 -955 . PDF |
| 36. | Shepherd GM, Pologruto TA, & Svoboda K. (2003) Circuit analysis of experience-dependent plasticity in the developing rat barrel cortex. Neuron 38, 277 -289 . PDF |
| 37. | Takahashi T, Svoboda K, & Malinow R. (2003) Experience strengthening transmission by driving AMPA receptors into synapses. Science 299, 1585 -1588 . PDF |
| 38. | Nimchinsky EA, Sabatini BL, Svoboda K. (2002) Structure and Function of Dendritic Spines. Annu. Rev. Physiol 64, 313 -353 . PDF |
| 39. | Oertner TG, Sabatini BL, Nimchinsky EA, & Svoboda K. (2002) Facilitation at single synapses probed with optical quantal analysis. Nature Neuroscience 5, 657 -664 . PDF |
| 40. | Oertner TG & Svoboda K. (2002) Subliminal messages in hippocampal pyramidal cells. J Physiology 543, 397 -397 . PDF |
| 41. | Zito K & Svoboda K. (2002) Activity-dependent synaptogenesis in the adult Mammalian cortex. Neuron 35, 1015 -1017 . PDF |
| 42. | Trachtenberg JT, Chen BE, Knott GW, Feng G, Sanes JR, Welker E, & Svoboda K.. (2002) Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex.. Nature 420, 788 -794 . PDF |
| 43. | Koh IY, Lindquist WB, Zito K, Nimchinsky EA, Svoboda K. (2002) An image analysis algorithm for dendritic spines. Neural Computation 14, 1283 -1310 . PDF |
| 44. | Sabatini, B.L., T.G. Oertner, and K. Svoboda. (2002) The life cycle of Ca2+ ions in dendritic spines. Neuron 33, 439 -452 . PDF |
| 45. | Stern EA, Maravall M, Svoboda K. (2001) Rapid development and plasticity of layer 2/3 maps in rat barrel cortex in vivo. Neuron 31, 305 -315 . PDF |
| 46. | Nimchinsky EA, Oberlander AM, Svoboda K. (2001) Abnormal development of dendritic spines in FMR1 knock-out mice. J. Neuroscience 21, 5139 -5146 . PDF |
| 47. | Sabatini BL, Maravall M, Svoboda K. (2001) Ca(2+) signaling in dendritic spines. Curr. Opin. Neurobiology 11, 349 -356 . PDF |
| 48. | Chen BE, Lendvai B, Nimchinsky EA, Burbach B, Fox K, Svoboda K. (2000) Imaging high-resolution structure of GFP-expressing neurons in neocortex in vivo. Learning and Development 7, 433 -441 . PDF |
| 49. | Cox CL, Denk W, Tank DW, Svoboda K. (2000) Action potentials reliably invade axonal arbors of rat neocortical neurons. Proc Natl Acad Sci USA 97, 9724 -9728 . PDF |
| 50. | Lendvai B, Stern EA, Chen B, Svoboda K. (2000) Experience-dependent plasticity of dendritic spines in the developing rat barrel cortex in vivo. Nature 404, 876 -881 . PDF |
| 51. | Maravall, M., Mainen, Z.F., Sabatini, B.L., & Svoboda, K. (2000) Estimating intracellular calcium concentrations and buffering without wavelength ratioing. Biophysical Journal 78, 2655 -2667 . PDF |
| 52. | Sabatini, B.L. and K. Svoboda. (2000) Analysis of calcium channels in single spines using optical fluctuation analysis. Nature 408, 589 -593 . PDF |
| 53. | Helmchen F, Svoboda K, Denk W, Tank DW. (1999) In vivo dendritic calcium dynamics in deep-layer cortical pyramidal neurons. Nature Neuroscience 2, 989 -996 . PDF |
| 54. | Shi SH, Hayashi Y, Petralia RS, Zaman SH, Wenthold RJ, Svoboda K, Malinow R. (1999) Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation. Science 284, 1811 -1816 . PDF |
| 55. | Mainen ZF, Maletic-Savatic M, Shi SH, Hayashi Y, Malinow R, Svoboda K. (1999) Two-photon imaging in living brain slices. Methods 18, 231 -239 . PDF |
| 56. | Mainen ZF, Malinow R, Svoboda K. (1999) Synaptic calcium transients in single spines indicate that NMDA receptors are not saturated. Nature 399, 151 -155 . PDF |
| 57. | Svoboda K, Mainen ZF. (1999) Synaptic [Ca2+]: intracellular stores spill their guts. Neuron 22, 427 -430 . PDF |
| 58. | Svoboda K, Helmchen F, Denk W, Tank DW. (1999) Spread of dendritic excitation in layer 2/3 pyramidal neurons in rat barrel cortex in vivo. Nature Neuroscience 2, 65 -73 . PDF |
| 59. | Maletic-Savatic M, Malinow R, Svoboda K. (1999) Rapid dendritic morphogenesis in CA1 hippocampal dendrites induced by synaptic activity. Science 283, 1923 -1927 . PDF |
| 60. | Maletic-Savatic, M., R. Malinow, and K. Svoboda. (1999) Rapid dendritic morphogenesis in CA1 hippocampal dendrites induced by synaptic activity. Science 283, 1923 -1927 . PDF |
| 61. | Svoboda K. (1998) Shining light on spiny matters. Nature Neuroscience 1, 93 -94 . PDF |
| 62. | Denk W, Svoboda K. (1997) Photon upmanship: why multiphoton imaging is more than a gimmick. Neuron 18, 351 -357 . PDF |
| 63. | Svoboda K, Denk W, Kleinfeld D, Tank DW. (1997) In vivo dendritic calcium dynamics in neocortical pyramidal neurons. Nature 385, 161 -165 . PDF |
| 64. | Denk W, Yuste R, Svoboda K, Tank DW. (1996) Imaging calcium dynamics in dendritic spines. Curr. Opin. Neurobiology 6, 372 -378 . PDF |
| 65. | Svoboda K, Tank DW, Denk W. (1996) Direct measurement of coupling between dendritic spines and shafts. Science 272, 716 -719 . PDF |
| 66. | Svoboda K. (1996) New insights into the workings of the ultimate swimming machine. Biophysical Journal 71, 539 -540 . |
| 67. | Block SM, Svoboda K. (1995) Analysis of high resolution recordings of motor movement. Biophysical Journal 68, 2305 -2395 . |
| 68. | Svoboda K, Mitra PP, Block SM. (1995) Fluctuation analysis of kinesin movement. Biophysical Journal 68, 69S . |
| 69. | Yin H, Wang MD, Svoboda K, Landick R, Block SM, Gelles J. (1995) Transcription against an applied force. Science 270, 1653 -1657 . |
| 70. | Latour LL, Svoboda K, Mitra PP, Sotak CH. (1994) Time-dependent diffusion of water in a biological model system. Proc. Natl. Acad. Sci. USA 91, 1229 -1233 . PDF |
| 71. | Svoboda K, Mitra PP, Block SM. (1994) Fluctuation analysis of motor protein movement and single enzyme kinetics. Proc. Natl. Acad.Sci. USA 91, 11782 -11786 . PDF |
| 72. | Svoboda K, Block SM. (1994) Biological applications of optical forces. Annu Rev Biophys Biomol Struct 23, 247 -285 . |
| 73. | Svoboda K, & Block SM. (1994) Force and velocity measured for single kinesin molecules. Cell 77, 773 -784 . |
| 74. | Schmidt CF, Svoboda K, Lei N, Petsche IB, Berman LE, Safinya CR, Grest GS. (1993) Existence of a flat phase in red cell membrane skeletons. Science 259, 952 -955 . |
| 75. | Svoboda K, Schmidt CF, Schnapp BJ, Block SM. (1993) Direct observation of kinesin stepping by optical trapping interferometry. Nature 365, 721 -727 . PDF |
| 76. | Svoboda K, Schmidt CF, Branton D, Block SM. (1992) Conformation and elasticity of the isolated red blood cell membrane skeleton. Biophysical Journal 63, 784 -793 . |